Radiation Injury: Mechanism of Toxicity and Countermeasures

Authors

  • Alok Kumar Soni [1] Institute of Pharmaceutical Sciences, SAGE University Indore, Madhya Pradesh, INDIA. [2] Defence Research and Development Establishment Jhansi Road Gwalior, Madhya Pradesh, INDIA.
  • Ankita Soni Department of Zoology, Government College Manawar, Dhar, Madhya Pradesh, INDIA.
  • Neeraj Upmanyu School of Pharmacy, Peoples University, Bhopal, Madhya Pradesh, INDIA.
  • Gurusamy Mathu Kannan Defence Research and Development Establishment Jhansi Road Gwalior, Madhya Pradesh, INDIA.
  • Nirmal Dongre Institute of Pharmaceutical Sciences, SAGE University Indore, Madhya Pradesh, INDIA.

DOI:

https://doi.org/10.5530/fra.2021.2.7

Keywords:

Radiation biology, Oxidative stress, Inflammation, Acute radiation effects, Chronic radiation effects, Radiation countermeasures

Abstract

This paper aims to review the basic concept of radiation biology and better understand the mechanism of toxicity when interacting with living tissue. The main content of this review includes the source of radiations, unit and measurement, mechanism of tissue injury and possible effects from that exposure; theoretic dose-response curves and their uses in radiation biology; stochastic versus non-stochastic effects of radiation exposure possible acute and chronic radiation exposure effects. Apart from that, we have also reviewed the recent development and progress available as well as under investigation, potential countermeasures compounds against the radiation-induced injury.

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Author Biographies

Alok Kumar Soni, [1] Institute of Pharmaceutical Sciences, SAGE University Indore, Madhya Pradesh, INDIA. [2] Defence Research and Development Establishment Jhansi Road Gwalior, Madhya Pradesh, INDIA.

Institute of Pharmaceutical Sciences, Asst. Prof

Ankita Soni, Department of Zoology, Government College Manawar, Dhar, Madhya Pradesh, INDIA.

Department of Zoology, Asst. Prof.

Neeraj Upmanyu, School of Pharmacy, Peoples University, Bhopal, Madhya Pradesh, INDIA.

Professor & Principal

Gurusamy Mathu Kannan, Defence Research and Development Establishment Jhansi Road Gwalior, Madhya Pradesh, INDIA.

Pharmacology and Toxicology, Scientist E

Nirmal Dongre, Institute of Pharmaceutical Sciences, SAGE University Indore, Madhya Pradesh, INDIA.

Institute of Pharmaceutical Sciences, Prof and Head

Radiation mediated redox and inflammatory imbalance.

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Published

2021-12-31
CITATION
DOI: 10.5530/fra.2021.2.7
Published: 2021-12-31

How to Cite

Soni, A. K., Soni, A., Upmanyu, N., Kannan, G. M., & Dongre, N. (2021). Radiation Injury: Mechanism of Toxicity and Countermeasures. Free Radicals and Antioxidants, 11(2), 29–34. https://doi.org/10.5530/fra.2021.2.7