@article{Alelign_Debella_Petros_2021, title={Evaluations of Antioxidant Effects of Selected Medicinal Plant Extracts Claimed to Treat Kidney Stone Disease}, volume={10}, url={https://www.antiox.org/index.php/fra/article/view/292}, DOI={10.5530/fra.2020.2.12}, abstractNote={<p style="text-align: justify;"><strong>Introduction:</strong> Free radicals are capable of inducing oxidative damage, which causes various human diseases. However, antioxidants reduce the risk of diseases related to reactive oxygen species. Medicinal plants such as <em>Achyranthes aspera</em> leaves, <em>Satureja punctata</em> aerial parts, <em>Aloe pulcherrima</em> gel, <em>Gomphocarpus fruticosus</em> leaves and<em> Commiphora myrrha</em> resins were claimed to treat various ailments including urolithiasis in Ethiopia. <strong>Objectives:</strong> This study was intended to determine phytochemicals and antioxidant activities of the aforementioned plants. <strong>Materials and Methods: </strong>Plants were collected and the aqueous crude extracts were prepared. Phytochemicals were screened qualitatively and DPPH(2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay was measured at 517nm using UV-Vis spectrophotometry. Data were analyzed statistically using one-way ANOVA, Dunnett’s comparison test of the Graph Pad Prism version 6. <strong>Results:</strong> The plant extracts exhibited various phytochemicals such as phenols, flavonoids and tannins, while these were absent in <em>C. myrrha</em>. Steroids and terpenoides were absent in <em>A. pulcherrima</em> and <em>G. fruticosus</em> extracts, respectively. DPPH scavenging capacities of <em>S. punctata, G. fruticosus, A. pulcherrima</em> and <em>A. aspera</em> aqueous extracts were 92.3%, 81.6%, 72.3% and 54.9%, respectively compared to control (Ascorbic acid) showed 87.6%, 94.5%, 92.3% and 95.6%, respectively at inhibitory concentrations of 0.20 mg/ml, 0.78 mg/ ml, 3.13 mg/ml and 12.5 mg/ml, respectively. The IC<sub>50</sub> antioxidant values of<em> S. punctata</em>, <em>A. pulcherrima, G. fruticosus,</em> and <em>A. aspera </em>extracts were 0.01 ±0.003 mg/ml, 0.42 ±0.047 mg/ml, 1.64 ±0.147 mg/ml, and 13.51 ±1.08 mg/ml, respectively compared to Ascorbic acid (0.03 ±0.007 mg/ml). <strong>Conclusion:</strong> The phytoconstituents in <em>S. punctata</em> aqueous extract has the best capability to scavenge DPPH free radicals. Future characterizations of compounds responsible for the antioxidant activities will be required.</p>}, number={2}, journal={Free Radicals and Antioxidants}, author={Alelign, Tilahun and Debella, Asfaw and Petros, Beyene}, year={2021}, month={Jan.}, pages={63–68} }