Cardioprotective Effect of Ethanolic Extract of Leaves of Amaranthus cruentus in Isoprenaline-Induced Myocardial Infarction in Rats

Authors

  • Priya Bisen Shri Ram Institute of Technology- Pharmacy, Jabalpur, Madhya Pradesh, INDIA.
  • Aman Chaturvedi Shri Ram Institute of Technology- Pharmacy, Jabalpur, Madhya Pradesh, INDIA.
  • Aditya Ganeshpurkar Shri Ram Institute of Technology- Pharmacy, Jabalpur, Madhya Pradesh, INDIA.
  • Nazneen Dubey Shri Ram Institute of Technology- Pharmacy, Jabalpur, Madhya Pradesh, INDIA.

DOI:

https://doi.org/10.5530/fra.2020.1.5

Keywords:

Amaranthus cruentus, Isoprenaline, Cardiotoxicity, Myocardialinfraction, Cholesterol, Lipid, Cardiac markers

Abstract

Objectives: The present study is focused to evaluate cardioprotective activity of ethanolic extract of Amaranthus cruentus. Methods: Amaranthus cruentus extract (Dose 200mg/kg and 400mg/kg) in isoprenaline induced myocardial infarction in rats. The ethanolic extract of Amaranthus cruentus was prepared and subjected to acute toxicity in albino rats. The extract was given orallyat two different doses 200mg/kg and 400mg/. Isoprenaline was administered subcutaneously (85mg/kg s.c.). Results: The histopathological examination revealed mild infarction and inflammation in isoprenaline treated rats. The ethanolic extract of Amaranthus cruentus showed significant cardio protective effect by decreasing the serum level of LDL and VLDL cholesterol levels. The biochemical parameters (AST, ALT and ALP) and HDL cholesterol levels were restored. Conclusion: The outcome of the present study suggested cardioprotective activity of Amaranthus cruentus extract.

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Figure 7: Evidence for the protective effect of Amaranthus cruentus extract in rats treated with isoprenaline; (a) normal control, (b) Isoprenaline, (c) Atrovastatin (d) Hesperidin 25 mg/kg p.o (e) Amaranthus cruentus 200 mg/kg p.o., (f ) Amaranthus cruentus 400 mg/kg p.o.,

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Published

2020-08-01

How to Cite

Bisen, P., Chaturvedi, A., Ganeshpurkar, A., & Dubey, N. (2020). Cardioprotective Effect of Ethanolic Extract of Leaves of Amaranthus cruentus in Isoprenaline-Induced Myocardial Infarction in Rats. Free Radicals and Antioxidants, 10(1), 24–28. https://doi.org/10.5530/fra.2020.1.5

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