Phytochemical Profile and Comparative Anti-radical Scavenging Activities of n-Hexane Extracts of Indigenous Zingiber officinale and Curcuma longa

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Abstract
Free Radicals and Antioxidants,2019,9,2,xx-xx.
Published:August 2019
Type:Original Article
Authors:
Author(s) affiliations:

Chibuzo Carole Nweze1,*, Emeka John Dingwoke2, Fatima Amin Adamude3, Nwobodo Ndubuisi Nwobodo4,5

1Department of Biochemistry, Nasarawa State University, Keffi, Nasarawa State, NIGERIA.

2Department of Biochemistry, Ahmadu Bello University, Zaria, Kaduna State, NIGERIA.

3Department of Medical Biochemistry, Federal University, Lafia, Nasarawa State, NIGERIA.

4Department of Pharmacology and Therapeutics, College of Medicine, Enugu State University of Science & Technology, Enugu State, NIGERIA.

5Department of Pharmacology and Therapeutics, College of Health Sciences, Nile University of Nigeria, FCT, Abuja, NIGERIA.

Abstract:

Objectives: The therapeutic and nutritional values of plants and plant produce for aliment management and as food supplements are evolving. Free radical scavenging activities of n-haxane extracts of indigenous Curcuma longa and Zingiber officinale was investigated and compared to CellGevity®; a nutraceutical antioxidant supplement. In addition, their phytochemical profile was qualitatively and quantitatively determined using standard procedure for phytochemical analysis. Methods: The antioxidant activities of the extracts were determined spectrophotometrically. We used 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, 2,2’-Azinobis3- ethylbenzothialine-6-sulfonic acid (ABTS) radical cations and hydrogen peroxide (H2O2) to determine free radical scavenging activities of the extracts. The ability of the extracts to scavenge free radicals was determined following the discoloration of the solution mixtures, measured spectrophotometrically. The reducing power efficacy of the extracts was determined by their ability to reduce Fe3+ to Fe2+ ions. Results: Curcuma longa and Zingiber officinale have more free radical scavenging power compared to CellGevity®. Curcuma longa has more scavenging power against DPPH and H2O2 system, while Zingiber officinale has more scavenging power against ABTS cations. CellGevity® had the least scavenging activity against the free radicals, as observed in this study. The highest phenolic, flavonoid, vitamin C, vitamin B1 and vitamin B2 quantified were found in Curcuma longa and Zingiber officinale compared to CellGevity®. Conclusion: The indigenous Curcuma longa and Zingiber officinale are natural sources of effective antioxidants with more scavenging power compared to a standard CellGevity® nutraceutical.